Immunotherapy in inflammatory bowel disease

D. B. Sachar, D. H. Present

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Immunosuppressive drugs are potentially dangerous. Their routine use in ulcerative colitis, a premalignant and surgically curable disease, is not advisable except as a short-term measure in patients intolerant of steroids or sulfasalazine and unwilling or unable to accept colectomy. They have a better-defined role in Crohn's disease, on the other hand, since this condition is incurable and potentially more mutilating. Here they have been reliably shown to have a steroid-sparing effect, to be at least as beneficial as sulfasalazine, and in some cases to produce healing of chronic enterocutaneous and perianal fistulae. However, the accurate prediction of which patients will benefit from azathioprine and which patients will not remains an as yet unfulfilled challenge for the future.

Original languageEnglish
Pages (from-to)173-183
Number of pages11
JournalMedical Clinics of North America
Issue number1
StatePublished - 1978
Externally publishedYes


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