Immunophilins in protein folding and immunosuppression

David A. Fruman, Steven J. Burakoff, Barbara E. Bierer

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


Lymphocyte activation requires the transmission of signals from molecules at the plasma membrane to nuclear signals that regulate gene expression. In recent years, several immunosuppressive compounds have been used as probes to identify important and potentially novel molecules involved in lymphocyte signal transduction processes. The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin have been studied in particular detail. Two distinct classes of immunosuppressant binding proteins have been identified, and collectively termed immunophilins. The cyclophilin family of immunophilins binds CsA, whereas the FK506-binding protein (FKBP) family binds FK506 and rapamycin. This review will discuss both the endogenous functions of immunophilins as well as their roles in mediating immunosuppression.

Original languageEnglish
Pages (from-to)391-400
Number of pages10
JournalFASEB Journal
Issue number6
StatePublished - 1994
Externally publishedYes


  • FK506
  • FKBP
  • calcineurin
  • cyclophilin
  • cyclosporin A
  • rapamycin


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