Immunophenotypic analysis of lymphocytes and myeloma cells in patients with multiple myeloma

Chihiro Shimazaki, Jerrold Fried, Amaury G. Perez, David A. Scheinberg, Jens Atzpodien, Chang Y. Wang, Rosanne Wisniewolski, Bayard D. Clarkson

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The immunological phenotypes of lymphocytes and myeloma cells in 48 patients with multiple myeloma (MM) were analyzed using a panel of monoclonal antibodies (mAbs). Myeloma cells were positive for OKTIO, BL3, PCA1 and BA2. In afew cases, they were also positive for the B cell-associated antigens J5, B1 and 12. Eight of 48 cases had more than 15% J5-positive lymphocytes, and some lymphocytes in MM expressed plasma cell-associated antigens (PCA1, BL3, OKTIO), suggesting a possible clonal involvement. These observations demonstrate the heterogeneity of surface antigen expression of myeloma cells and suggest that BL3, PCA1, BA2 and J5 may be useful mAbs for purging myeloma cells from bone marrow for autologous transplantation.

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalActa Haematologica
Volume83
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Immunophenotype
  • Monoclonal antibodies
  • Multiple myeloma
  • Plasma cells

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