Immunopathogenesis of hepatitis B virus infection

J. Judy Chang; Sharon R. Lewin

doi:10.1038/sj.icb.7100009

Immunopathogenesis of hepatitis B virus infection

J. Judy Chang, Sharon R. Lewin

Research output: Contribution to journal › Review article › peer-review

162 Scopus citations

Abstract

Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.

Original language	English
Pages (from-to)	16-23
Number of pages	8
Journal	Immunology and Cell Biology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1038/sj.icb.7100009
State	Published - 28 Jan 2007
Externally published	Yes

Keywords

Cirrhosis
Hepatitis B virus
Immunology
Immunopathogenesis
Innate immunity
T-cells

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10.1038/sj.icb.7100009

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abstract = "Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.",

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AU - Lewin, Sharon R.

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AB - Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.

KW - Cirrhosis

KW - Hepatitis B virus

KW - Immunology

KW - Immunopathogenesis

KW - Innate immunity

KW - T-cells

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Immunopathogenesis of hepatitis B virus infection

Abstract

Keywords

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