Immunological distinction between the possible origins of enzymatic activity in a polypeptide fragment of staphylococcal nuclease

David H. Sachs, Alan N. Schechter, Ann Eastlake, Christian B. Anfinsen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

WE have used an immunological approach to demonstrate that the residual enzymatic activity in a large polypeptide fragment of staphylococcal nuclease is an intrinsic property of the fragment and not an artefact due to contamination with intact enzyme. These results are consistent with present concepts of the folding of polypeptide fragments to form structures similar to the native protein and may offer a method for the investigation of other macromolecular systems.

Original languageEnglish
Pages (from-to)242-244
Number of pages3
JournalNature
Volume251
Issue number5472
DOIs
StatePublished - 1974
Externally publishedYes

Fingerprint

Dive into the research topics of 'Immunological distinction between the possible origins of enzymatic activity in a polypeptide fragment of staphylococcal nuclease'. Together they form a unique fingerprint.

Cite this