Immunologic, microbial, and epithelial interactions in atopic dermatitis

Patrick M. Brunner; Donald Y.M. Leung; Emma Guttman-Yassky

doi:10.1016/j.anai.2017.09.055

Immunologic, microbial, and epithelial interactions in atopic dermatitis

Patrick M. Brunner, Donald Y.M. Leung, Emma Guttman-Yassky

Research output: Contribution to journal › Review article › peer-review

129 Scopus citations

Abstract

Objective To provide an overview of studies contributing to the understanding of immunologic, microbial, and epithelial interactions in atopic dermatitis. Data Sources PubMed literature review (2000–2017) and meeting abstracts from recent international dermatology conferences. Study Selections Articles discussing primarily human disease. Results Clinical studies showed that atopic dermatitis is a type 2 immune-centered disease with a systemic inflammatory component but with heterogeneous treatment responses. This suggests that other factors are likely involved in shaping the skin disease phenotype, including microbial dysbiosis and epidermal barrier dysfunction. Conclusion Recent clinical investigation has significantly expanded our knowledge on disease pathogenesis in atopic dermatitis, and current and future clinical trials will most likely further help to elucidate this complex, heterogeneous skin disease.

Original language	English
Pages (from-to)	34-41
Number of pages	8
Journal	Annals of Allergy, Asthma and Immunology
Volume	120
Issue number	1
DOIs	https://doi.org/10.1016/j.anai.2017.09.055
State	Published - Jan 2018

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title = "Immunologic, microbial, and epithelial interactions in atopic dermatitis",

abstract = "Objective To provide an overview of studies contributing to the understanding of immunologic, microbial, and epithelial interactions in atopic dermatitis. Data Sources PubMed literature review (2000–2017) and meeting abstracts from recent international dermatology conferences. Study Selections Articles discussing primarily human disease. Results Clinical studies showed that atopic dermatitis is a type 2 immune-centered disease with a systemic inflammatory component but with heterogeneous treatment responses. This suggests that other factors are likely involved in shaping the skin disease phenotype, including microbial dysbiosis and epidermal barrier dysfunction. Conclusion Recent clinical investigation has significantly expanded our knowledge on disease pathogenesis in atopic dermatitis, and current and future clinical trials will most likely further help to elucidate this complex, heterogeneous skin disease.",

author = "Brunner, {Patrick M.} and Leung, {Donald Y.M.} and Emma Guttman-Yassky",

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AU - Leung, Donald Y.M.

AU - Guttman-Yassky, Emma

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N2 - Objective To provide an overview of studies contributing to the understanding of immunologic, microbial, and epithelial interactions in atopic dermatitis. Data Sources PubMed literature review (2000–2017) and meeting abstracts from recent international dermatology conferences. Study Selections Articles discussing primarily human disease. Results Clinical studies showed that atopic dermatitis is a type 2 immune-centered disease with a systemic inflammatory component but with heterogeneous treatment responses. This suggests that other factors are likely involved in shaping the skin disease phenotype, including microbial dysbiosis and epidermal barrier dysfunction. Conclusion Recent clinical investigation has significantly expanded our knowledge on disease pathogenesis in atopic dermatitis, and current and future clinical trials will most likely further help to elucidate this complex, heterogeneous skin disease.

AB - Objective To provide an overview of studies contributing to the understanding of immunologic, microbial, and epithelial interactions in atopic dermatitis. Data Sources PubMed literature review (2000–2017) and meeting abstracts from recent international dermatology conferences. Study Selections Articles discussing primarily human disease. Results Clinical studies showed that atopic dermatitis is a type 2 immune-centered disease with a systemic inflammatory component but with heterogeneous treatment responses. This suggests that other factors are likely involved in shaping the skin disease phenotype, including microbial dysbiosis and epidermal barrier dysfunction. Conclusion Recent clinical investigation has significantly expanded our knowledge on disease pathogenesis in atopic dermatitis, and current and future clinical trials will most likely further help to elucidate this complex, heterogeneous skin disease.

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Immunologic, microbial, and epithelial interactions in atopic dermatitis

Abstract

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