Immunologic consequences of chemotherapy for acute myeloid leukemia

Anne Reilly, Leslie S. Kersun, Eline Luning Prak, Jean Boyer, Kenyetta McDonald, Abbas F. Jawad, Kathleen E. Sullivan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


There are few data characterizing the immunologic consequences of chemotherapy for acute myeloid leukemia (AML) and almost nothing is known about the effects of chemotherapy in a pediatric AML cohort. We identified T-cell subsets, B-cell subsets, and used Enzyme-linked immunosorbent spot analyses to define the function of T cells and B cells in 7 pediatric patients with AML on chemotherapy. The data show that the effects of chemotherapy disproportionately target the B cell and depletion of B cells is associated with impaired responses to the inactivated influenza vaccine. Diminished T-cell numbers were also observed although the magnitude of the effect was less than what was seen for B cells. Furthermore, measures of T-cell function were largely intact. We conclude that humoral immunity is significantly affected by chemotherapy for AML.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalJournal of Pediatric Hematology/Oncology
Issue number1
StatePublished - Jan 2013
Externally publishedYes


  • B cell
  • T cell
  • influenza
  • vaccine


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