Immunohistochemical expression of fibronectin in the lungs of fire victims proves intravital reaction in fatal burns

Michael Bohnert, Jürina Anderson, Markus A. Rothschild, Joachim Böhm

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Immunohistochemical studies about the presence of fibronectin in the lungs were performed in a group of 73 fire victims (63 cases of intravital and 10 cases of postmortem burn) as well as in an unselected control group of 55 individuals not exposed to fire before death. The cases of intravital burn showed a significantly stronger fibronectin expression than the control cases and the cases of postmortem burn. Fibronectin was mainly present in macrophages of the peribronchial lung parenchyma and, not associated with cells, in the matrix of peribronchial tissue. Our findings suggest that higher levels of fibronectin expression in the lung tissue of burn victims compared to fire-unrelated deaths may serve as an indicator of an early intravital inflammatory response to fire damage.

Original languageEnglish
Pages (from-to)583-588
Number of pages6
JournalInternational Journal of Legal Medicine
Volume124
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Burns
  • Diagnosis of vitality
  • Fibronectin
  • Inhalational trauma
  • Lungs

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