Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus

John H. Morrison; Robert Benoit; Pierre J. Magistretti; Nicholas Ling; Floyd E. Bloom

doi:10.1016/0304-3940(82)90165-3

Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus

John H. Morrison
, Robert Benoit
, Pierre J. Magistretti
, Nicholas Ling
, Floyd E. Bloom

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

By using immune sera which recognize one or more of the 3 peptides, somatostatin 14 (SS14), somatostatin-28 (SS28) and somatostatin-28_1-12) (SS28_1-12) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS28_1-12 is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	Neuroscience Letters
Volume	34
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(82)90165-3
State	Published - 30 Dec 1982
Externally published	Yes

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title = "Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus",

abstract = "By using immune sera which recognize one or more of the 3 peptides, somatostatin 14 (SS14), somatostatin-28 (SS28) and somatostatin-281-12) (SS281-12) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS281-12 is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.",

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doi = "10.1016/0304-3940(82)90165-3",

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T1 - Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus

AU - Morrison, John H.

AU - Benoit, Robert

AU - Magistretti, Pierre J.

AU - Ling, Nicholas

AU - Bloom, Floyd E.

PY - 1982/12/30

Y1 - 1982/12/30

N2 - By using immune sera which recognize one or more of the 3 peptides, somatostatin 14 (SS14), somatostatin-28 (SS28) and somatostatin-281-12) (SS281-12) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS281-12 is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.

AB - By using immune sera which recognize one or more of the 3 peptides, somatostatin 14 (SS14), somatostatin-28 (SS28) and somatostatin-281-12) (SS281-12) we have characterized their immunohistochemical distribution in the hippocampal formation. There exist at least two independent neuronal systems containing pro-somatostatin-related peptides: an intrinsic system of cells in the polymorphic layers which branch locally, and a dense terminal field in the molecular layer of the dentate gyrus that may constitute a portion of the entorhinal-dentate projection. In addition, SS28 is the dominant form present in cell bodies, whereas SS281-12 is preferentially localized in neuronal processes and terminals. We could not detect SS14 immunohistochemically.

UR - https://www.scopus.com/pages/publications/0020351425

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DO - 10.1016/0304-3940(82)90165-3

M3 - Article

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AN - SCOPUS:0020351425

SN - 0304-3940

VL - 34

SP - 137

EP - 142

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus

Abstract

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