Immunohistochemical and electron microscopic studies of langerhans' cell histiocytosis (eosinophilic granuloma) of the orbit

I. Rand Rodgers, Ramon L. Font, Alan H. Friedman, Samuel L. Guillory, Frederick A. Jakobiec, Milton Boniuk

Research output: Contribution to journalArticlepeer-review

Abstract

Immunophenotypic and histochemical studies have shown that Langerhans' cell histiocytosis results from an abnormal proliferation of dendritic cells. Characterized by a cytoplasm containing Birbeck granules and S-100 protein, these cells elaborate the surface glycoprotein T-6. We report here two cases of eosinophilic granuloma and review the immunologic role of Langerhans' cells with attention focused upon their unique morphologic traits.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalClinical and Refractive Optometry
Volume18
Issue number4
StatePublished - 2007

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