Immunophenotypic and histochemical studies have shown that Langerhans' cell histiocytosis results from an abnormal proliferation of dendritic cells. Characterized by a cytoplasm containing Birbeck granules and S-100 protein, these cells elaborate the surface glycoprotein T-6. We report here two cases of eosinophilic granuloma and review the immunologic role of Langerhans' cells with attention focused upon their unique morphologic traits.
|Number of pages||6|
|State||Published - Jan 2003|