Immunoglobulin Studies in Patients With Psychiatric Diseases

Raymond P. Roos, Kenneth Davis, Herbert Y. Meltzer

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Autoimmune processes and viral infections have been proposed as causative factors in psychiatric diseases. To investigate this issue, we screened serum and CSF from schizophrenic and depressed patients for quantitative and qualitative immunoglobulin abnormalities. Qualitative immunoglobulin abnormalities were assessed by isoelectric focusing (IEF) since the presence of IEF oligoclonal immunoglobulin bands is a feature of viral and autoimmune diseases. We found no significant elevation of immunoglobulin levels or increased incidence of oligoclonal immunoglobulin bands, suggesting that viruses and autoimmunity are not involved in the major psychoses.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalArchives of General Psychiatry
Issue number2
StatePublished - Feb 1985
Externally publishedYes


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