Immunoglobulin disorders of the small bowel

R. H. Marshak, A. E. Lindner, D. Maklansky

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Advances in immunology have permitted recognition of a group of patients who have gastrointestinal manifestations as part of an immunoglobulin deficiency syndrome. Such immunoglobulin deficiency may be primary or may be secondary to a variety of diseases. The authors have classified and described the small bowel roentgen features associated with the various immunoglobulin deficiency syndromes as follows: the sprue pattern, as seen in hypogammaglobulinemic sprue and in IgA deficient sprue; multiple nodular defects; inflammatory changes secondary to giardiasis, associated with immune deficiency diseases; and thickening of the small intestinal folds, as seen in the plasma cell dyscrasias, lymphoma, intestinal lymphangiectasia, and amyloidosis.

Original languageEnglish
Pages (from-to)477-491
Number of pages15
JournalRadiologic Clinics of North America
Issue number3
StatePublished - 1976


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