Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV

Kristin L. DeBord; Deborah M. Anderson; Melanie M. Marketon; Katie A. Overheim; R. William DePaolo; Nancy A. Ciletti; Bana Jabri; Olaf Schneewind

doi:10.1128/IAI.01860-05

Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV

Kristin L. DeBord, Deborah M. Anderson, Melanie M. Marketon, Katie A. Overheim, R. William DePaolo, Nancy A. Ciletti, Bana Jabri, Olaf Schneewind

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.

Original language	English
Pages (from-to)	4910-4914
Number of pages	5
Journal	Infection and Immunity
Volume	74
Issue number	8
DOIs	https://doi.org/10.1128/IAI.01860-05
State	Published - Aug 2006
Externally published	Yes

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DeBord, K. L., Anderson, D. M., Marketon, M. M., Overheim, K. A., DePaolo, R. W., Ciletti, N. A., Jabri, B., & Schneewind, O. (2006). Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV. Infection and Immunity, 74(8), 4910-4914. https://doi.org/10.1128/IAI.01860-05

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abstract = "In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.",

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AU - Overheim, Katie A.

AU - DePaolo, R. William

AU - Ciletti, Nancy A.

AU - Jabri, Bana

AU - Schneewind, Olaf

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AB - In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV10 may serve as an improved plague vaccine.

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Immunogenicity and protective immunity against bubonic plague and pneumonic plague by immunization of mice with the recombinant V10 antigen, a variant of LcrV

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