Immunoediting instructs tumor metabolic reprogramming to support immune evasion

Chin Hsien Tsai, Yu Ming Chuang, Xiaoyun Li, Yi Ru Yu, Sheue Fen Tzeng, Shao Thing Teoh, Katherine E. Lindblad, Mario Di Matteo, Wan Chen Cheng, Pei Chun Hsueh, Kung Chi Kao, Hana Imrichova, Likun Duan, Hector Gallart-Ayala, Pei Wen Hsiao, Massimiliano Mazzone, Julijana Ivanesevic, Xiaojing Liu, Karin E. de Visser, Amaia LujambioSophia Y. Lunt, Susan M. Kaech, Ping Chih Ho

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumorigenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early-stage tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tumor-immune interaction is controlled by non-canonical interferon gamma (IFNγ)-STAT3 signaling and supports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvironment.

Original languageEnglish
Pages (from-to)118-133.e7
JournalCell Metabolism
Issue number1
StatePublished - 3 Jan 2023


  • IFNγ
  • Myc
  • STAT3
  • immunoediting
  • immunosurveillance
  • tumor immunology


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