TY - JOUR
T1 - Immune Thrombocytopenia Following α-Interferon Therapy in Patients With Cancer
AU - McLaughlin, Peter
AU - Talpaz, Moshe
AU - Quesada, Jorge R.
AU - Saleem, Abdus
AU - Barlogie, Barthel
AU - Gutterman, Jordan U.
PY - 1985/9/13
Y1 - 1985/9/13
N2 - Immune thrombocytopenia occurred in five patients with cancer receiving α-interferon. The median pretreatment platelet count was 217,000/cu mm, which fell to a median of 12,000/cu mm after a median of 25 days of interferon therapy. All had normal numbers of megakaryocytes, with dysplasia noted in three; all four who were tested had platelet-associated immunoglobulin. All had normalization of platelet counts with prednisone therapy. Four tolerated re-treatment with interferon, two with concurrent prednisone administration and two others following splenectomy. Immune thrombocytopenia should be considered in patients who become thrombocytopenic during interferon therapy.
AB - Immune thrombocytopenia occurred in five patients with cancer receiving α-interferon. The median pretreatment platelet count was 217,000/cu mm, which fell to a median of 12,000/cu mm after a median of 25 days of interferon therapy. All had normal numbers of megakaryocytes, with dysplasia noted in three; all four who were tested had platelet-associated immunoglobulin. All had normalization of platelet counts with prednisone therapy. Four tolerated re-treatment with interferon, two with concurrent prednisone administration and two others following splenectomy. Immune thrombocytopenia should be considered in patients who become thrombocytopenic during interferon therapy.
UR - http://www.scopus.com/inward/record.url?scp=84871179574&partnerID=8YFLogxK
U2 - 10.1001/jama.1985.03360100103022
DO - 10.1001/jama.1985.03360100103022
M3 - Article
C2 - 4021013
AN - SCOPUS:84871179574
SN - 0098-7484
VL - 254
SP - 1353
EP - 1354
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 10
ER -