@article{a5f643eb720343ffa0f6f18e1d74bdcb,
title = "Immune responses to human immunodeficiency virus (HIV) type 1 induced by canarypox expressing HIV-1(MN) gp120, HIV-1(SF2) recombinant gp120, or both vaccines in seronegative adults",
abstract = "A safety and immunogenicity trial was conducted in vaccinia-immune and vaccinia-naive human immunodeficiency virus (HIV)-uninfected adults who were randomized to receive 106 or 107 TCID50 of canarypox (ALVAC) vector expressing HIV-1(MN) gp160 or 105.5 TCID50 of ALVAC-rabies virus glycoprotein control at 0 and 1 or 2 months and ALVAC-gp160 or 50 μg of HIV- 1(SF2) recombinant (r) gp120 in microfluidized emulsion at 9 and 12 months; others received rgp120 at 0, 1, 6, and 12 months. All vaccines were well- tolerated. Neither vaccinia-immune status before vaccination nor ALVAC dose affected HIV immune responses. HIV-1(MN) and HIV-1(SF2) neutralizing antibodies were detected more often (100%) in ALVAC-gp160/rgp120 recipients than in recipients of ALVAC-gp160 (<65%) or rgp120 (89%) alone. ALVAC- gp160/rgp120 also elicited more frequent HIV V3-specific and fusion- inhibition antibodies, antibody-dependent cellular cytotoxicity, lymphoproliferation, and cytotoxic CD8+ T cell activity than did either vaccine alone. Trials with ALVAC expressing additional HIV components and rgp120 are underway.",
author = "Clements-Mann, {Mary Lou} and Kent Weinhold and Matthews, {Thomas J.} and Graham, {Barney S.} and Gorse, {Geoffrey J.} and Keefer, {Michael C.} and {Juliana McElrath}, M. and Hsieh, {Ray Hahn} and Jiri Mestecky and Susan Zolla-Pazner and John Mascola and David Schwartz and Robert Siliciano and Lawrence Corey and Wright, {Peter F.} and Robert Belshe and Raphael Dolin and Susan Jackson and Serena Xu and Patricia Fast and Walker, {Mary Clare} and Don Stablein and Excler, {Jean Louis} and James Tartaglia and Duliege, {Anne Marie} and Faruk Sinangil and Enzo Paoletti",
note = "Funding Information: Financial support: NIH (AI-45207, Johns Hopkins University; AI-45211, St. Louis University; AI-45208, University of Rochester; AI-45210, Vanderbilt University; AI-45209, University of Washington; AI-65305, Duke University; AI-35163, University of Alabama at Birmingham; AI-32424 and AI-27742, New York University Medical Center; AI-82500, EMMES Corp.); support from the Research Center for AIDS and HIV Infection (VA Medical Center); and cooperative agreement no. DAMD17-93-V-3004 between the US Army Medical Research and Materiel Command and the Henry M. Jackson Foundation for the Advancement of Military Medicine.",
year = "1998",
doi = "10.1086/515288",
language = "English",
volume = "177",
pages = "1230--1246",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}