Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells

Erdem Bangi, Chrysoula Pitsouli, Laurence G. Rahme, Ross Cagan, Yiorgos Apidianakis

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Although pathogenic bacteria are suspected contributors to colorectal cancer progression, cancer-promoting bacteria and their mode of action remain largely unknown. Here we report that sustained infection with the human intestinal colonizer Pseudomonas aeruginosa synergizes with the Ras1 V12 oncogene to induce basal invasion and dissemination of hindgut cells to distant sites. Cross-talk between infection and dissemination requires sustained activation by the bacteria of the Imd-dTab2-dTak1 innate immune pathway, which converges with Ras1 V12 signalling on JNK pathway activation, culminating in extracellular matrix degradation. Hindgut, but not midgut, cells are amenable to this cooperative dissemination, which is progressive and genetically and pharmacologically inhibitable. Thus, Drosophila hindgut provides a valuable system for the study of intestinal malignancies.

Original languageEnglish
Pages (from-to)569-576
Number of pages8
JournalEMBO Reports
Issue number6
StatePublished - Jun 2012


  • Drosophila
  • cancer
  • innate immunity


Dive into the research topics of 'Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells'. Together they form a unique fingerprint.

Cite this