Immune response modeling of interferon β-pretreated influenza virus-infected human dendritic cells

Liang Qiao; Hannah Phipps-Yonas; Boris Hartmann; Thomas M. Moran; Stuart C. Sealfon; Fernand Hayot

doi:10.1016/j.bpj.2009.10.049

Immune response modeling of interferon β-pretreated influenza virus-infected human dendritic cells

Liang Qiao, Hannah Phipps-Yonas, Boris Hartmann, Thomas M. Moran, Stuart C. Sealfon, Fernand Hayot

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The pretreatment of human dendritic cells with interferon-β enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.

Original language	English
Pages (from-to)	505-514
Number of pages	10
Journal	Biophysical Journal
Volume	98
Issue number	4
DOIs	https://doi.org/10.1016/j.bpj.2009.10.049
State	Published - 17 Feb 2010

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title = "Immune response modeling of interferon β-pretreated influenza virus-infected human dendritic cells",

abstract = "The pretreatment of human dendritic cells with interferon-β enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.",

author = "Liang Qiao and Hannah Phipps-Yonas and Boris Hartmann and Moran, {Thomas M.} and Sealfon, {Stuart C.} and Fernand Hayot",

note = "Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases contract HHSN266200500021C, and National Institutes of Health grants U19 AI62623 and RO1 AI041111. ",

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T1 - Immune response modeling of interferon β-pretreated influenza virus-infected human dendritic cells

AU - Qiao, Liang

AU - Phipps-Yonas, Hannah

AU - Hartmann, Boris

AU - Moran, Thomas M.

AU - Sealfon, Stuart C.

AU - Hayot, Fernand

N1 - Funding Information: This work was supported by the National Institute of Allergy and Infectious Diseases contract HHSN266200500021C, and National Institutes of Health grants U19 AI62623 and RO1 AI041111.

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N2 - The pretreatment of human dendritic cells with interferon-β enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.

AB - The pretreatment of human dendritic cells with interferon-β enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.

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JO - Biophysical Journal

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Immune response modeling of interferon β-pretreated influenza virus-infected human dendritic cells

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