Immune response and mitosis of human peripheral blood lymphocytes in vitro

Kurt Hirschhorn, Fritz Bach, Roselyn L. Kolodny, I. Lester Firschein, Nemat Hashem

Research output: Contribution to journalArticlepeer-review

142 Scopus citations

Abstract

Phytohemagglutinin causes cultured lymphocytes to agglutinate, divide, and produce γ-globulin. Most cells are transformed into large lymphocytes, some resembling plasmocytes. Actinomycin D stops γ-globulin production after 2 hours. When specific antigens are added to lymphocytes from sensitized individuals, only some cells undergo morphological transformation, produce γ-globulin, and divide. When cells or cell extracts from an unrelated individual are added to a culture, a similar reaction occurs.

Original languageEnglish
Pages (from-to)1185-1187
Number of pages3
JournalScience
Volume142
Issue number3596
DOIs
StatePublished - 1963
Externally publishedYes

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