Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients

Jéromine Klingler; Gregory S. Lambert; Juan C. Bandres; Rozita Emami-Gorizi; Arthur Nádas; Kasopefoluwa Y. Oguntuyo; Fatima Amanat; Maria C. Bermúdez-González; Charles Gleason; Giulio Kleiner; Viviana Simon; Benhur Lee; Susan Zolla-Pazner; Chitra Upadhyay; Catarina E. Hioe

doi:10.1016/j.isci.2022.105608

Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients

Jéromine Klingler, Gregory S. Lambert, Juan C. Bandres, Rozita Emami-Gorizi, Arthur Nádas, Kasopefoluwa Y. Oguntuyo, Fatima Amanat, Maria C. Bermúdez-González, Charles Gleason, Giulio Kleiner, Viviana Simon, Benhur Lee, Susan Zolla-Pazner, Chitra Upadhyay, Catarina E. Hioe

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19.

Original language	English
Article number	105608
Journal	iScience
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.isci.2022.105608
State	Published - 22 Dec 2022

Keywords

Health sciences
Immune response
Immunology
Population

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Klingler, J., Lambert, G. S., Bandres, J. C., Emami-Gorizi, R., Nádas, A., Oguntuyo, K. Y., Amanat, F., Bermúdez-González, M. C., Gleason, C., Kleiner, G., Simon, V., Lee, B., Zolla-Pazner, S., Upadhyay, C., & Hioe, C. E. (2022). Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients. iScience, 25(12), Article 105608. https://doi.org/10.1016/j.isci.2022.105608

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title = "Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients",

abstract = "A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19.",

keywords = "Health sciences, Immune response, Immunology, Population",

author = "J{\'e}romine Klingler and Lambert, {Gregory S.} and Bandres, {Juan C.} and Rozita Emami-Gorizi and Arthur N{\'a}das and Oguntuyo, {Kasopefoluwa Y.} and Fatima Amanat and Berm{\'u}dez-Gonz{\'a}lez, {Maria C.} and Charles Gleason and Giulio Kleiner and Viviana Simon and Benhur Lee and Susan Zolla-Pazner and Chitra Upadhyay and Hioe, {Catarina E.}",

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doi = "10.1016/j.isci.2022.105608",

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Klingler, J, Lambert, GS, Bandres, JC, Emami-Gorizi, R, Nádas, A, Oguntuyo, KY, Amanat, F, Bermúdez-González, MC, Gleason, C, Kleiner, G, Simon, V , Lee, B , Zolla-Pazner, S, Upadhyay, C & Hioe, CE 2022, 'Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients', iScience, vol. 25, no. 12, 105608. https://doi.org/10.1016/j.isci.2022.105608

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AU - Klingler, Jéromine

AU - Lambert, Gregory S.

AU - Bandres, Juan C.

AU - Emami-Gorizi, Rozita

AU - Nádas, Arthur

AU - Oguntuyo, Kasopefoluwa Y.

AU - Amanat, Fatima

AU - Bermúdez-González, Maria C.

AU - Gleason, Charles

AU - Kleiner, Giulio

AU - Simon, Viviana

AU - Lee, Benhur

AU - Zolla-Pazner, Susan

AU - Upadhyay, Chitra

AU - Hioe, Catarina E.

PY - 2022/12/22

Y1 - 2022/12/22

N2 - A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19.

AB - A fraction of patients with COVID-19 develops severe disease requiring hospitalization, while the majority, including high-risk individuals, experience mild symptoms. Severe disease has been associated with higher levels of antibodies and inflammatory cytokines but often among patients with diverse demographics and comorbidity status. This study evaluated hospitalized vs. ambulatory patients with COVID-19 with demographic risk factors for severe COVID-19: median age of 63, >80% male, and >85% black and/or Hispanic. Sera were collected four to 243 days after symptom onset and evaluated for binding and functional antibodies as well as 48 cytokines and chemokines. SARS-CoV-2-specific antibody levels and functions were similar in ambulatory and hospitalized patients. However, a strong correlation between anti-S2 antibody levels and the other antibody parameters, along with higher IL-27 levels, was observed in hospitalized but not ambulatory cases. These data indicate that antibodies against the relatively conserved S2 spike subunit and immunoregulatory cytokines such as IL-27 are potential immune determinants of COVID-19.

KW - Health sciences

KW - Immune response

KW - Immunology

KW - Population

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VL - 25

JO - iScience

JF - iScience

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M1 - 105608

ER -

Immune profiles to distinguish hospitalized versus ambulatory COVID-19 cases in older patients

Abstract

Keywords

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