Immune-mediated skin diseases induced by chemicals and drugs

Axel P. Villani; Pia Gamradt; Audrey Nosbaum; Léo Laoubi; Denis Jullien; Jean François Nicolas; Marc Vocanson

doi:10.1016/j.cotox.2018.11.002

Immune-mediated skin diseases induced by chemicals and drugs

Axel P. Villani, Pia Gamradt, Audrey Nosbaum, Léo Laoubi, Denis Jullien, Jean François Nicolas, Marc Vocanson

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Immune-mediated skin diseases induced by chemicals and drugs are mainly T-cell mediated reactions, i.e. type IV hypersensitivity of the Gell & Coombs classification. Clinical expressions depend on the exposition route of the chemical with allergic contact dermatitis in case of skin exposure and delayed drug allergy in case of oral or parenteral intake. Allergic contact dermatitis and delayed drug allergy share common pathophysiologic pathways with chemical-specific T cells recruitment to the skin to eliminate chemical-expressing keratinocytes. In this review, we discuss the pathophysiology of allergic contact dermatitis and delayed drug allergy with focus on their common pathways.

Original language	English
Pages (from-to)	111-116
Number of pages	6
Journal	Current Opinion in Toxicology
Volume	10
DOIs	https://doi.org/10.1016/j.cotox.2018.11.002
State	Published - Aug 2018
Externally published	Yes

Keywords

Allergic contact dermatitis
Chemicals
Cutaneous adverse drug reactions
Drug
Maculo-papular exanthema
Toxic epidermal necrolysis

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10.1016/j.cotox.2018.11.002

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title = "Immune-mediated skin diseases induced by chemicals and drugs",

abstract = "Immune-mediated skin diseases induced by chemicals and drugs are mainly T-cell mediated reactions, i.e. type IV hypersensitivity of the Gell & Coombs classification. Clinical expressions depend on the exposition route of the chemical with allergic contact dermatitis in case of skin exposure and delayed drug allergy in case of oral or parenteral intake. Allergic contact dermatitis and delayed drug allergy share common pathophysiologic pathways with chemical-specific T cells recruitment to the skin to eliminate chemical-expressing keratinocytes. In this review, we discuss the pathophysiology of allergic contact dermatitis and delayed drug allergy with focus on their common pathways.",

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AU - Villani, Axel P.

AU - Gamradt, Pia

AU - Nosbaum, Audrey

AU - Laoubi, Léo

AU - Jullien, Denis

AU - Nicolas, Jean François

AU - Vocanson, Marc

PY - 2018/8

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N2 - Immune-mediated skin diseases induced by chemicals and drugs are mainly T-cell mediated reactions, i.e. type IV hypersensitivity of the Gell & Coombs classification. Clinical expressions depend on the exposition route of the chemical with allergic contact dermatitis in case of skin exposure and delayed drug allergy in case of oral or parenteral intake. Allergic contact dermatitis and delayed drug allergy share common pathophysiologic pathways with chemical-specific T cells recruitment to the skin to eliminate chemical-expressing keratinocytes. In this review, we discuss the pathophysiology of allergic contact dermatitis and delayed drug allergy with focus on their common pathways.

AB - Immune-mediated skin diseases induced by chemicals and drugs are mainly T-cell mediated reactions, i.e. type IV hypersensitivity of the Gell & Coombs classification. Clinical expressions depend on the exposition route of the chemical with allergic contact dermatitis in case of skin exposure and delayed drug allergy in case of oral or parenteral intake. Allergic contact dermatitis and delayed drug allergy share common pathophysiologic pathways with chemical-specific T cells recruitment to the skin to eliminate chemical-expressing keratinocytes. In this review, we discuss the pathophysiology of allergic contact dermatitis and delayed drug allergy with focus on their common pathways.

KW - Allergic contact dermatitis

KW - Chemicals

KW - Cutaneous adverse drug reactions

KW - Drug

KW - Maculo-papular exanthema

KW - Toxic epidermal necrolysis

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JO - Current Opinion in Toxicology

JF - Current Opinion in Toxicology

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Immune-mediated skin diseases induced by chemicals and drugs

Abstract

Keywords

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