Immune mechanisms of oral immunotherapy

Michael D. Kulis, Sarita U. Patil, Erik Wambre, Brian P. Vickery

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.

Original languageEnglish
Pages (from-to)491-498
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume141
Issue number2
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • B cells
  • Oral immunotherapy
  • T cells
  • antibodies
  • basophils
  • desensitization
  • immune mechanisms
  • mast cells
  • sustained unresponsiveness

Fingerprint

Dive into the research topics of 'Immune mechanisms of oral immunotherapy'. Together they form a unique fingerprint.

Cite this