Immune mechanisms of oral immunotherapy

Michael D. Kulis, Sarita U. Patil, Erik Wambre, Brian P. Vickery

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.

Original languageEnglish
Pages (from-to)491-498
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Issue number2
StatePublished - Feb 2018
Externally publishedYes


  • B cells
  • Oral immunotherapy
  • T cells
  • antibodies
  • basophils
  • desensitization
  • immune mechanisms
  • mast cells
  • sustained unresponsiveness


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