TY - JOUR
T1 - Immune mechanisms of HIV control
AU - Chakrabarti, Lisa A.
AU - Simon, Viviana
N1 - Funding Information:
The authors receive funding from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (R01AI064001, R01AI089246, VS), the Alexandrine and Alexander L. Sinsheimer Fund (VS), the Clinical and Translational Science Award to Mount Sinai School of Medicine (UL1RR029887, VS), the Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS EP36, LC), Sidaction (LC), and the Pasteur Institute (LC).
PY - 2010/8
Y1 - 2010/8
N2 - HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.
AB - HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.
UR - https://www.scopus.com/pages/publications/77955663456
U2 - 10.1016/j.coi.2010.06.006
DO - 10.1016/j.coi.2010.06.006
M3 - Review article
C2 - 20650621
AN - SCOPUS:77955663456
SN - 0952-7915
VL - 22
SP - 488
EP - 496
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -