Immune mechanisms of HIV control

Lisa A. Chakrabarti, Viviana Simon

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.

Original languageEnglish
Pages (from-to)488-496
Number of pages9
JournalCurrent Opinion in Immunology
Volume22
Issue number4
DOIs
StatePublished - Aug 2010

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