@article{6befa6422d7147da82e93481d65cdb73,
title = "Immune exclusion-WNT/CTNNB1 class predicts resistance to immunotherapies in HCC",
abstract = "Next-generation sequencing has provided information on actionable targets and biomarkers of response in oncology. In hepatocellular carcinoma (HCC), Wnt/CTNNB1 mutations characterize the immune-excluded class (cold tumors) and might represent the biomarkers predicting resistance to immune checkpoint inhibitors. Large-scale validation of these data is needed to customize immunotherapy in advanced HCC.",
author = "Roser Pinyol and Daniela Sia and Llovet, {Josep M.}",
note = "Funding Information: R. Pinyol is funded by the EC and EIT Health. D. Sia is supported by the Gilead Sciences Research Scholar Program in Liver Disease. J.M. Llovet is supported by the NCI (P30-CA196521), U.S. Department of Defense (CA150272P3), European Commission (EC)/Horizon 2020 Program (HEPCAR, Ref. 667273-2), EIT Health (CRISH2, Ref. 18053), Accelerator Award (CRUK, AECC, AIRC; HUNTER, Ref. C9380/A26813), Samuel Waxman Cancer Research Foundation, Spanish NIH (SAF2016-76390), and Generalitat de Catalunya/AGAUR (SGR-1358). Publisher Copyright: {\textcopyright} 2019 American Association for Cancer Research.",
year = "2019",
month = apr,
day = "1",
doi = "10.1158/1078-0432.CCR-18-3778",
language = "English",
volume = "25",
pages = "2021--2023",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "7",
}