Abstract
Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.
Original language | English |
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Pages (from-to) | e9-e16 |
Journal | Urologic Clinics of North America |
Volume | 47 |
Issue number | 4 |
DOIs | |
State | Published - Nov 2020 |
Keywords
- IFN-γ signaling
- Immune evasion
- Immunotherapy
- Prostate cancer