Immune Escape in Prostate Cancer: Known and Predicted Mechanisms and Targets

Boris A. Reva, Tatiana Omelchenko, Sujit S. Nair, Ashutosh K. Tewari

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.

Original languageEnglish
Pages (from-to)e9-e16
JournalUrologic Clinics of North America
Volume47
Issue number4
DOIs
StatePublished - Nov 2020

Keywords

  • IFN-γ signaling
  • Immune evasion
  • Immunotherapy
  • Prostate cancer

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