Immune Escape in Prostate Cancer: Known and Predicted Mechanisms and Targets

Boris A. Reva; Tatiana Omelchenko; Sujit S. Nair; Ashutosh K. Tewari

doi:10.1016/j.ucl.2020.10.004

Immune Escape in Prostate Cancer: Known and Predicted Mechanisms and Targets

Boris A. Reva, Tatiana Omelchenko, Sujit S. Nair, Ashutosh K. Tewari

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.

Original language	English
Pages (from-to)	e9-e16
Journal	Urologic Clinics of North America
Volume	47
Issue number	4
DOIs	https://doi.org/10.1016/j.ucl.2020.10.004
State	Published - Nov 2020

Keywords

IFN-γ signaling
Immune evasion
Immunotherapy
Prostate cancer

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@article{664ffaeab1c0429fbcf15a92fc7b1850,

title = "Immune Escape in Prostate Cancer: Known and Predicted Mechanisms and Targets",

abstract = "Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.",

keywords = "IFN-γ signaling, Immune evasion, Immunotherapy, Prostate cancer",

author = "Reva, {Boris A.} and Tatiana Omelchenko and Nair, {Sujit S.} and Tewari, {Ashutosh K.}",

note = "Funding Information: The authors wish to acknowledge funding support from the Deane Prostate Health, ISMMS, and The Arthur M. Blank Family Foundation to AKT. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

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language = "English",

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T1 - Immune Escape in Prostate Cancer

T2 - Known and Predicted Mechanisms and Targets

AU - Reva, Boris A.

AU - Omelchenko, Tatiana

AU - Nair, Sujit S.

AU - Tewari, Ashutosh K.

N1 - Funding Information: The authors wish to acknowledge funding support from the Deane Prostate Health, ISMMS, and The Arthur M. Blank Family Foundation to AKT. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/11

Y1 - 2020/11

N2 - Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.

AB - Complex immune evasion mechanisms and lack of biomarkers predicting responsiveness to immune checkpoint blockade therapies compromise immunotherapy's therapeutic efficacy for patients with prostate cancer. The authors review established and nominated immune evasion mechanisms in prostate cancer and discuss how the precise treatment strategies can be developed to improve efficacy of immunotherapy.

KW - IFN-γ signaling

KW - Immune evasion

KW - Immunotherapy

KW - Prostate cancer

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U2 - 10.1016/j.ucl.2020.10.004

DO - 10.1016/j.ucl.2020.10.004

M3 - Review article

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AN - SCOPUS:85097734512

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JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

IS - 4

ER -

Immune Escape in Prostate Cancer: Known and Predicted Mechanisms and Targets

Abstract

Keywords

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