Immune diseases caused by mutations in kinases and components of the ubiquitin system

Philip Cohen

doi:10.1038/ni.2892

Immune diseases caused by mutations in kinases and components of the ubiquitin system

Philip Cohen

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

The signaling networks that control the immune system are coordinated by a myriad of interconnecting phosphorylation and ubiquitylation events. This review provides an overview of mutations in human genes encoding these proteins that give rise to immune diseases. Analysis of the biological effects of these mutations has revealed the true physiological roles of particular signaling networks and promises to revolutionize the treatment of these diseases.

Original language	English
Pages (from-to)	521-529
Number of pages	9
Journal	Nature Immunology
Volume	15
Issue number	6
DOIs	https://doi.org/10.1038/ni.2892
State	Published - Jun 2014
Externally published	Yes

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10.1038/ni.2892

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Immune diseases caused by mutations in kinases and components of the ubiquitin system

Abstract

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