Immune Checkpoint Blockade for Genitourinary Malignancies and the Abscopal Response

Binbin Zheng-Lin, Matthew D. Galsky

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In order to control the amplitude and duration of T-cell inflammatory response, our immune system has evolved a series of checks and balances commonly referred to as immune checkpoints. Unfortunately, cancer cells exploit such checkpoints to evade immune-mediated rejection. A recognition of the role of adaptive immune resistance in cancer growth and progression has led to the development of immune checkpoint inhibitors (ICIs) as cancer therapies. Within just a few years of introduction of ICIs into the clinic, these agents have become a pillar of standard treatment across a range of malignancies. Genitourinary cancers, particularly renal cancer and urothelial cancer, have figured prominently in the initial clinical development of ICIs. Here, we discuss the role of ICIs in the treatment of genitourinary malignancies and address the potential immunomodulatory role of local ablative therapies.

Original languageEnglish
Title of host publicationInterventional Urology, Second Edition
PublisherSpringer International Publishing
Pages551-559
Number of pages9
ISBN (Electronic)9783030735654
ISBN (Print)9783030735647
DOIs
StatePublished - 1 Jan 2021

Keywords

  • Abscopal effect
  • Bladder cancer
  • Cytotoxic T-lymphocyte associated protein 4 (CTLA-4)
  • Immune checkpoint inhibitor
  • Programmed cell death protein-1 (PD-1)
  • Prostate cancer
  • Radiotherapy
  • Renal cancer

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