TY - JOUR
T1 - Immune barriers of Ebola virus infection
AU - McElroy, Anita K.
AU - Mühlberger, Elke
AU - Muñoz-Fontela, César
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/2
Y1 - 2018/2
N2 - Since its initial emergence in 1976 in northern Democratic Republic of Congo (DRC), Ebola virus (EBOV) has been a global health concern due to its virulence in humans, the mystery surrounding the identity of its host reservoir and the unpredictable nature of Ebola virus disease (EVD) outbreaks. Early after the first clinical descriptions of a disease resembling a ‘septic-shock-like syndrome’ with coagulation abnormalities and multi-system organ failure, researchers began to evaluate the role of the host immune response in EVD pathophysiology. In this review, we summarize how data gathered during the last 40 years in the laboratory as well as in the field have provided insight into EBOV immunity. From molecular mechanisms involved in EBOV recognition in infected cells, to antigen processing and adaptive immune responses, we discuss current knowledge on the main immune barriers of infection as well as outstanding research questions.
AB - Since its initial emergence in 1976 in northern Democratic Republic of Congo (DRC), Ebola virus (EBOV) has been a global health concern due to its virulence in humans, the mystery surrounding the identity of its host reservoir and the unpredictable nature of Ebola virus disease (EVD) outbreaks. Early after the first clinical descriptions of a disease resembling a ‘septic-shock-like syndrome’ with coagulation abnormalities and multi-system organ failure, researchers began to evaluate the role of the host immune response in EVD pathophysiology. In this review, we summarize how data gathered during the last 40 years in the laboratory as well as in the field have provided insight into EBOV immunity. From molecular mechanisms involved in EBOV recognition in infected cells, to antigen processing and adaptive immune responses, we discuss current knowledge on the main immune barriers of infection as well as outstanding research questions.
UR - http://www.scopus.com/inward/record.url?scp=85042213179&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2018.01.010
DO - 10.1016/j.coviro.2018.01.010
M3 - Review article
C2 - 29452995
AN - SCOPUS:85042213179
SN - 1879-6257
VL - 28
SP - 152
EP - 160
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -