Immobilization Osteoporosis

William A. Bauman, Christopher P. Cardozo

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

12 Scopus citations


Immobilization osteoporosis represents a wide spectrum of conditions and disorders. Bone loss due to immobilizing conditions is a consequence of reduction in mechanical load. The etiology and severity of the immobilizing condition, anatomical region, age, gender, genetic factors, and duration are a few considerations that determine the location, magnitude, and characteristics of the observed accelerated skeletal deterioration. After severe immobilization-related bone loss, risk of fracture is increased in the short-term, or if less severe, increased when associated with age-related bony changes. Currently, the interventions intended to maintain bone during immobilization are often not efficacious. Animal models of immobilization, including those of limb casting, tenotomy, hindlimb unweighting, peripheral nerve transection, and spinal cord injury, have afforded knowledge and insight into the cellular, biochemical, and molecular changes that occur with immobilization/disuse, and have provided potential strategies to implement in an attempt to reduce the bone loss related to reduction in load.

Original languageEnglish
Title of host publicationOsteoporosis
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Number of pages33
ISBN (Print)9780124158535
StatePublished - Jun 2013


  • Acute paralytic poliomyelitis
  • Hindlimb
  • Immobilization osteoporosis
  • Myostatin
  • Osteocyte
  • Scoliosis
  • Spinal cord injury (SCI)
  • Stroke
  • Tenotomy


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