Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo; Benjamin E. Nilsson-Payant; Wen Chun Liu; Skyler Uhl; Daisy Hoagland; Rasmus Møller; Tristan X. Jordan; Kohei Oishi; Maryline Panis; David Sachs; Taia T. Wang; Robert E. Schwartz; Jean K. Lim; Randy A. Albrecht; Benjamin R. tenOever

doi:10.1016/j.cell.2020.04.026

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo
, Benjamin E. Nilsson-Payant
, Wen Chun Liu
, Skyler Uhl
, Daisy Hoagland
, Rasmus Møller
, Tristan X. Jordan
, Kohei Oishi
, Maryline Panis
, David Sachs
, Taia T. Wang
, Robert E. Schwartz
, Jean K. Lim
, Randy A. Albrecht
, Benjamin R. tenOever

Research output: Contribution to journal › Article › peer-review

3351 Scopus citations

Abstract

In comparison to other respiratory viruses, SARS-CoV-2 infection drives a lower antiviral transcriptional response that is marked by low IFN-I and IFN-III levels and elevated chemokine expression, which could explain the pro-inflammatory disease state associated with COVID-19.

Original language	English
Pages (from-to)	1036-1045.e9
Journal	Cell
Volume	181
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.04.026
State	Published - 28 May 2020

Keywords

COVID-19
Coronavirus
IL6
SARS-CoV-2
chemokines
ferret
interferon
transcriptomics
virus-host interactions

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10.1016/j.cell.2020.04.026

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@article{182c0426c5bb4a6fb3044ac38be49148,

title = "Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19",

abstract = "In comparison to other respiratory viruses, SARS-CoV-2 infection drives a lower antiviral transcriptional response that is marked by low IFN-I and IFN-III levels and elevated chemokine expression, which could explain the pro-inflammatory disease state associated with COVID-19.",

keywords = "COVID-19, Coronavirus, IL6, SARS-CoV-2, chemokines, ferret, interferon, transcriptomics, virus-host interactions",

author = "Daniel Blanco-Melo and Nilsson-Payant, \{Benjamin E.\} and Liu, \{Wen Chun\} and Skyler Uhl and Daisy Hoagland and Rasmus M{\o}ller and Jordan, \{Tristan X.\} and Kohei Oishi and Maryline Panis and David Sachs and Wang, \{Taia T.\} and Schwartz, \{Robert E.\} and Lim, \{Jean K.\} and Albrecht, \{Randy A.\} and tenOever, \{Benjamin R.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = may,

day = "28",

doi = "10.1016/j.cell.2020.04.026",

language = "English",

volume = "181",

pages = "1036--1045.e9",

journal = "Cell",

issn = "0092-8674",

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T1 - Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

AU - Blanco-Melo, Daniel

AU - Nilsson-Payant, Benjamin E.

AU - Liu, Wen Chun

AU - Uhl, Skyler

AU - Hoagland, Daisy

AU - Møller, Rasmus

AU - Jordan, Tristan X.

AU - Oishi, Kohei

AU - Panis, Maryline

AU - Sachs, David

AU - Wang, Taia T.

AU - Schwartz, Robert E.

AU - Lim, Jean K.

AU - Albrecht, Randy A.

AU - tenOever, Benjamin R.

PY - 2020/5/28

Y1 - 2020/5/28

N2 - In comparison to other respiratory viruses, SARS-CoV-2 infection drives a lower antiviral transcriptional response that is marked by low IFN-I and IFN-III levels and elevated chemokine expression, which could explain the pro-inflammatory disease state associated with COVID-19.

AB - In comparison to other respiratory viruses, SARS-CoV-2 infection drives a lower antiviral transcriptional response that is marked by low IFN-I and IFN-III levels and elevated chemokine expression, which could explain the pro-inflammatory disease state associated with COVID-19.

KW - COVID-19

KW - Coronavirus

KW - IL6

KW - SARS-CoV-2

KW - chemokines

KW - ferret

KW - interferon

KW - transcriptomics

KW - virus-host interactions

UR - https://www.scopus.com/pages/publications/85084438244

U2 - 10.1016/j.cell.2020.04.026

DO - 10.1016/j.cell.2020.04.026

M3 - Article

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AN - SCOPUS:85084438244

SN - 0092-8674

VL - 181

SP - 1036-1045.e9

JO - Cell

JF - Cell

IS - 5

ER -

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Abstract

Keywords

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