Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen Chun Liu, Skyler Uhl, Daisy Hoagland, Rasmus Møller, Tristan X. Jordan, Kohei Oishi, Maryline Panis, David Sachs, Taia T. Wang, Robert E. Schwartz, Jean K. Lim, Randy A. Albrecht, Benjamin R. tenOever

Research output: Contribution to journalArticlepeer-review

2641 Scopus citations


In comparison to other respiratory viruses, SARS-CoV-2 infection drives a lower antiviral transcriptional response that is marked by low IFN-I and IFN-III levels and elevated chemokine expression, which could explain the pro-inflammatory disease state associated with COVID-19.

Original languageEnglish
Pages (from-to)1036-1045.e9
Issue number5
StatePublished - 28 May 2020


  • COVID-19
  • Coronavirus
  • IL6
  • SARS-CoV-2
  • chemokines
  • ferret
  • interferon
  • transcriptomics
  • virus-host interactions


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