Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Daniel Blanco-Melo, Benjamin E. Nilsson-Payant, Wen Chun Liu, Skyler Uhl, Daisy Hoagland, Rasmus Møller, Tristan X. Jordan, Kohei Oishi, Maryline Panis, David Sachs, Taia T. Wang, Robert E. Schwartz, Jean K. Lim, Randy A. Albrecht, Benjamin R. tenOever

Research output: Contribution to journalArticlepeer-review

3018 Scopus citations

Abstract

In comparison to other respiratory viruses, SARS-CoV-2 infection drives a lower antiviral transcriptional response that is marked by low IFN-I and IFN-III levels and elevated chemokine expression, which could explain the pro-inflammatory disease state associated with COVID-19.

Original languageEnglish
Pages (from-to)1036-1045.e9
JournalCell
Volume181
Issue number5
DOIs
StatePublished - 28 May 2020

Keywords

  • COVID-19
  • Coronavirus
  • IL6
  • SARS-CoV-2
  • chemokines
  • ferret
  • interferon
  • transcriptomics
  • virus-host interactions

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