Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist

Sophia Huang; Dorine de Jong; Jeeban P. Das; Reginald Scott Widemon; Brian Braumuller; Jacienta Paily; Aileen Deng; Connie Liou; Tina Roa; Alice Huang; Hong Ma; Belinda D'Souza; Jay Leb; Jade L'Hereaux; Pamela Nguyen; Lyndon Luk; Mark Francescone; Randy Yeh; Valerie Maccarrone; Laurent Dercle; Mary M. Salvatore; Kathleen M. Capaccione

doi:10.1016/j.acra.2023.04.004

Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist

Sophia Huang, Dorine de Jong, Jeeban P. Das, Reginald Scott Widemon, Brian Braumuller, Jacienta Paily, Aileen Deng, Connie Liou, Tina Roa, Alice Huang, Hong Ma, Belinda D'Souza, Jay Leb, Jade L'Hereaux, Pamela Nguyen, Lyndon Luk, Mark Francescone, Randy Yeh, Valerie Maccarrone, Laurent DercleMary M. Salvatore, Kathleen M. Capaccione

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen. These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically. Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated.

Original language	English
Pages (from-to)	2712-2727
Number of pages	16
Journal	Academic Radiology
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.acra.2023.04.004
State	Published - Nov 2023
Externally published	Yes

Keywords

CAR T cell therapy
adverse events
imaging
immunology

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10.1016/j.acra.2023.04.004

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Huang, S., de Jong, D., Das, J. P., Widemon, R. S., Braumuller, B., Paily, J., Deng, A., Liou, C., Roa, T., Huang, A., Ma, H., D'Souza, B., Leb, J., L'Hereaux, J., Nguyen, P., Luk, L., Francescone, M., Yeh, R., Maccarrone, V., ... Capaccione, K. M. (2023). Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist. Academic Radiology, 30(11), 2712-2727. https://doi.org/10.1016/j.acra.2023.04.004

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title = "Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist",

abstract = "Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen. These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically. Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated.",

keywords = "CAR T cell therapy, adverse events, imaging, immunology",

author = "Sophia Huang and {de Jong}, Dorine and Das, {Jeeban P.} and Widemon, {Reginald Scott} and Brian Braumuller and Jacienta Paily and Aileen Deng and Connie Liou and Tina Roa and Alice Huang and Hong Ma and Belinda D'Souza and Jay Leb and Jade L'Hereaux and Pamela Nguyen and Lyndon Luk and Mark Francescone and Randy Yeh and Valerie Maccarrone and Laurent Dercle and Salvatore, {Mary M.} and Capaccione, {Kathleen M.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Association of University Radiologists",

year = "2023",

month = nov,

doi = "10.1016/j.acra.2023.04.004",

language = "English",

volume = "30",

pages = "2712--2727",

journal = "Academic Radiology",

issn = "1076-6332",

publisher = "Elsevier Inc.",

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}

Huang, S, de Jong, D, Das, JP, Widemon, RS, Braumuller, B, Paily, J, Deng, A, Liou, C, Roa, T, Huang, A, Ma, H, D'Souza, B, Leb, J, L'Hereaux, J, Nguyen, P, Luk, L, Francescone, M, Yeh, R, Maccarrone, V, Dercle, L, Salvatore, MM & Capaccione, KM 2023, 'Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist', Academic Radiology, vol. 30, no. 11, pp. 2712-2727. https://doi.org/10.1016/j.acra.2023.04.004

TY - JOUR

T1 - Imaging the Side Effects of CAR T Cell Therapy

T2 - A Primer for the Practicing Radiologist

AU - Huang, Sophia

AU - de Jong, Dorine

AU - Das, Jeeban P.

AU - Widemon, Reginald Scott

AU - Braumuller, Brian

AU - Paily, Jacienta

AU - Deng, Aileen

AU - Liou, Connie

AU - Roa, Tina

AU - Huang, Alice

AU - Ma, Hong

AU - D'Souza, Belinda

AU - Leb, Jay

AU - L'Hereaux, Jade

AU - Nguyen, Pamela

AU - Luk, Lyndon

AU - Francescone, Mark

AU - Yeh, Randy

AU - Maccarrone, Valerie

AU - Dercle, Laurent

AU - Salvatore, Mary M.

AU - Capaccione, Kathleen M.

PY - 2023/11

Y1 - 2023/11

N2 - Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen. These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically. Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated.

AB - Chimeric antigen receptor (CAR) T cell therapy is a revolutionary form of immunotherapy that has proven to be efficacious in the treatment of many hematologic cancers. CARs are modified T lymphocytes that express an artificial receptor specific to a tumor-associated antigen. These engineered cells are then reintroduced to upregulate the host immune responses and eradicate malignant cells. While the use of CAR T cell therapy is rapidly expanding, little is known about how common side effects such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS) present radiographically. Here we provide a comprehensive review of how side effects present in different organ systems and how they can be optimally imaged. Early and accurate recognition of the radiographic presentation of these side effects is critical to the practicing radiologist and their patients so that these side effects can be promptly identified and treated.

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KW - adverse events

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AN - SCOPUS:85163938288

SN - 1076-6332

VL - 30

SP - 2712

EP - 2727

JO - Academic Radiology

JF - Academic Radiology

IS - 11

ER -

Imaging the Side Effects of CAR T Cell Therapy: A Primer for the Practicing Radiologist

Abstract

Keywords

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