@inbook{f0c371e4c0d748048dce63dbde563e3f,
title = "Imaging the efficacy of anti-inflammatory liposomes in a rabbit model of atherosclerosis by non-invasive imaging",
abstract = " Nanomedicine can provide a potent alternative to current therapeutic strategies for atherosclerosis. For example, the encapsulation of anti-inflammatory drugs into liposomes improves their pharmacokinetics and biodistribution, thereby enhancing bioavailability to atherosclerotic plaques and improving therapeutic efficacy. The evaluation of this type of experimental therapeutics can greatly benefit from in vivo evaluation to assess biological changes, which can be performed by non-invasive imaging techniques, such as 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). Here, we will illustrate the methods for inducing atherosclerosis in a rabbit model, the production of anti-inflammatory liposomes and monitoring of therapeutic efficacy of experimental therapeutics with the above-mentioned imaging techniques.",
keywords = "Atherosclerosis, Balloon angioplasty, Liposome, Multimodal imaging, Nanomedicine, Noninvasive imaging, Therapeutic efficacy",
author = "Lobatto, {Mark E.} and Claudia Calcagno and Metselaar, {Josbert M.} and Gert Storm and Stroes, {Erik S.G.} and Fayad, {Zahi A.} and Mulder, {Willem J.M.}",
note = "Funding Information: M.E.L. is supported by the International Atherosclerosis Society and by the Foundation “De Drie Lichten” in The Netherlands. This work was supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, as a Program of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C, as well as by R01 EB009638 (Z.A.F.) and R01 CA155432 (W.J.M.M.).",
year = "2012",
doi = "10.1016/B978-0-12-391860-4.00011-2",
language = "English",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
pages = "211--228",
booktitle = "Methods in Enzymology",
address = "United States",
}