Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody

Rosemary B. Duda; J. David Beatty; Khalil Sheibani; Lawrence E. Williams; Raymond J. Paxton; Barbara G. Beatty; John E. Shively; William G. Vlahos; John L. Werner; M. Margaret Kemeny; William A. Kokal; Daniel U. Riihimaki; Lawrence D. Wagman; Jose J. Terz

doi:10.1001/archsurg.1986.01400110107018

Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody

Rosemary B. Duda, J. David Beatty, Khalil Sheibani, Lawrence E. Williams, Raymond J. Paxton, Barbara G. Beatty, John E. Shively, William G. Vlahos, John L. Werner, M. Margaret Kemeny, William A. Kokal, Daniel U. Riihimaki, Lawrence D. Wagman, Jose J. Terz

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Abstract

Twenty patients with 21 primary colorectal adenocarcinomas were studied with 2 mCi (7.6 ×10⁷ becquerels) of indium-labeled monoclonal antibody (200 μg) specific for carcinoembryonic antigen (CEA). Fifteen lesions (71%) were visualized by gamma camera scintigraphy at 48 hours postinjection. Tumors that were identified by immunoscintigraphy were large (38.10±17.76 cm³ vs 6.00±1.65 cm³), had a grossly fungating component, had a high content of CEA by enzyme immunoassay (12.9±3.6 μg/g vs 3.3±1.7 μg/g), and had an apical and/or intraluminal staining pattern on immunohistologic section. Patients whose tumors were visualized had a low serum CEA level (1.9±0.4 ng/mL vs 14.6± 8.0 ng/mL). Prospective selection of patients for follow-up imaging or therapy with radiolabeled monoclonal antibodies may be feasible using these measurements.

Original language	English
Pages (from-to)	1315-1319
Number of pages	5
Journal	Archives of Surgery
Volume	121
Issue number	11
DOIs	https://doi.org/10.1001/archsurg.1986.01400110107018
State	Published - Nov 1986
Externally published	Yes

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Duda, R. B., David Beatty, J., Sheibani, K., Williams, L. E., Paxton, R. J., Beatty, B. G., Shively, J. E., Vlahos, W. G., Werner, J. L., Kemeny, M. M., Kokal, W. A., Riihimaki, D. U., Wagman, L. D., & Terz, J. J. (1986). Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody. Archives of Surgery, 121(11), 1315-1319. https://doi.org/10.1001/archsurg.1986.01400110107018

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title = "Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody",

abstract = "Twenty patients with 21 primary colorectal adenocarcinomas were studied with 2 mCi (7.6 ×107 becquerels) of indium-labeled monoclonal antibody (200 μg) specific for carcinoembryonic antigen (CEA). Fifteen lesions (71%) were visualized by gamma camera scintigraphy at 48 hours postinjection. Tumors that were identified by immunoscintigraphy were large (38.10±17.76 cm3 vs 6.00±1.65 cm3), had a grossly fungating component, had a high content of CEA by enzyme immunoassay (12.9±3.6 μg/g vs 3.3±1.7 μg/g), and had an apical and/or intraluminal staining pattern on immunohistologic section. Patients whose tumors were visualized had a low serum CEA level (1.9±0.4 ng/mL vs 14.6± 8.0 ng/mL). Prospective selection of patients for follow-up imaging or therapy with radiolabeled monoclonal antibodies may be feasible using these measurements.",

author = "Duda, {Rosemary B.} and {David Beatty}, J. and Khalil Sheibani and Williams, {Lawrence E.} and Paxton, {Raymond J.} and Beatty, {Barbara G.} and Shively, {John E.} and Vlahos, {William G.} and Werner, {John L.} and Kemeny, {M. Margaret} and Kokal, {William A.} and Riihimaki, {Daniel U.} and Wagman, {Lawrence D.} and Terz, {Jose J.}",

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Duda, RB, David Beatty, J, Sheibani, K, Williams, LE, Paxton, RJ, Beatty, BG, Shively, JE, Vlahos, WG, Werner, JL, Kemeny, MM, Kokal, WA, Riihimaki, DU, Wagman, LD & Terz, JJ 1986, 'Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody', Archives of Surgery, vol. 121, no. 11, pp. 1315-1319. https://doi.org/10.1001/archsurg.1986.01400110107018

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AU - Paxton, Raymond J.

AU - Beatty, Barbara G.

AU - Shively, John E.

AU - Vlahos, William G.

AU - Werner, John L.

AU - Kemeny, M. Margaret

AU - Kokal, William A.

AU - Riihimaki, Daniel U.

AU - Wagman, Lawrence D.

AU - Terz, Jose J.

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N2 - Twenty patients with 21 primary colorectal adenocarcinomas were studied with 2 mCi (7.6 ×107 becquerels) of indium-labeled monoclonal antibody (200 μg) specific for carcinoembryonic antigen (CEA). Fifteen lesions (71%) were visualized by gamma camera scintigraphy at 48 hours postinjection. Tumors that were identified by immunoscintigraphy were large (38.10±17.76 cm3 vs 6.00±1.65 cm3), had a grossly fungating component, had a high content of CEA by enzyme immunoassay (12.9±3.6 μg/g vs 3.3±1.7 μg/g), and had an apical and/or intraluminal staining pattern on immunohistologic section. Patients whose tumors were visualized had a low serum CEA level (1.9±0.4 ng/mL vs 14.6± 8.0 ng/mL). Prospective selection of patients for follow-up imaging or therapy with radiolabeled monoclonal antibodies may be feasible using these measurements.

AB - Twenty patients with 21 primary colorectal adenocarcinomas were studied with 2 mCi (7.6 ×107 becquerels) of indium-labeled monoclonal antibody (200 μg) specific for carcinoembryonic antigen (CEA). Fifteen lesions (71%) were visualized by gamma camera scintigraphy at 48 hours postinjection. Tumors that were identified by immunoscintigraphy were large (38.10±17.76 cm3 vs 6.00±1.65 cm3), had a grossly fungating component, had a high content of CEA by enzyme immunoassay (12.9±3.6 μg/g vs 3.3±1.7 μg/g), and had an apical and/or intraluminal staining pattern on immunohistologic section. Patients whose tumors were visualized had a low serum CEA level (1.9±0.4 ng/mL vs 14.6± 8.0 ng/mL). Prospective selection of patients for follow-up imaging or therapy with radiolabeled monoclonal antibodies may be feasible using these measurements.

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Imaging of Human Colorectal Adenocarcinoma With Indium-Labeled Anticarcinoembryonic Antigen Monoclonal Antibody

Abstract

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