Imaging human intra-cerebral connectivity by PET during TMS

Peter Fox; Roger Ingham; Mark S. George; Helen Mayberg; Janis Ingham; John Roby; Charles Martin; Paul Jerabek

doi:10.1097/00001756-199708180-00027

Imaging human intra-cerebral connectivity by PET during TMS

Peter Fox, Roger Ingham, Mark S. George, Helen Mayberg, Janis Ingham, John Roby, Charles Martin, Paul Jerabek

Research output: Contribution to journal › Article › peer-review

367 Scopus citations

Abstract

NON-INVASIVE imaging of human inter-regional neural connectivity by positron emission tomography (PET) during transcranial magnetic stimulation (TMS) was performed. The hand area of primary motor cortex (M1) in the left cerebral hemisphere was stimulated with TMS while local and remote effects were recorded with PET. At the stimulated site, TMS increased blood flow (12- 20%) in a highly focal manner, without an inhibitory surround. Remote covariances, an index of connectivity with M1, were also focal. Connectivity patterns established in non-human species were generally confirmed. Excitatory connectivity (positive covariance) was observed in ipsilateral primary and secondary somatosensory areas (S1 and S2), in ipsilateral ventral, lateral premotor cortex (M2) and in contralateral supplementary motor area (SMA). Inhibitory connectivity (negative covariance) was observed in contralateral M1.

Original language	English
Pages (from-to)	2787-2791
Number of pages	5
Journal	NeuroReport
Volume	8
Issue number	12
DOIs	https://doi.org/10.1097/00001756-199708180-00027
State	Published - 1997
Externally published	Yes

Keywords

Connectivity
Human
M2
Positron emission tomography (PET)
Primary motor cortex (M1)
S1
S2
SMA
Transcranial magnetic stimulation (TMS)

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10.1097/00001756-199708180-00027

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title = "Imaging human intra-cerebral connectivity by PET during TMS",

abstract = "NON-INVASIVE imaging of human inter-regional neural connectivity by positron emission tomography (PET) during transcranial magnetic stimulation (TMS) was performed. The hand area of primary motor cortex (M1) in the left cerebral hemisphere was stimulated with TMS while local and remote effects were recorded with PET. At the stimulated site, TMS increased blood flow (12- 20%) in a highly focal manner, without an inhibitory surround. Remote covariances, an index of connectivity with M1, were also focal. Connectivity patterns established in non-human species were generally confirmed. Excitatory connectivity (positive covariance) was observed in ipsilateral primary and secondary somatosensory areas (S1 and S2), in ipsilateral ventral, lateral premotor cortex (M2) and in contralateral supplementary motor area (SMA). Inhibitory connectivity (negative covariance) was observed in contralateral M1.",

keywords = "Connectivity, Human, M2, Positron emission tomography (PET), Primary motor cortex (M1), S1, S2, SMA, Transcranial magnetic stimulation (TMS)",

author = "Peter Fox and Roger Ingham and George, {Mark S.} and Helen Mayberg and Janis Ingham and John Roby and Charles Martin and Paul Jerabek",

year = "1997",

doi = "10.1097/00001756-199708180-00027",

language = "English",

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pages = "2787--2791",

journal = "NeuroReport",

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T1 - Imaging human intra-cerebral connectivity by PET during TMS

AU - Fox, Peter

AU - Ingham, Roger

AU - George, Mark S.

AU - Mayberg, Helen

AU - Ingham, Janis

AU - Roby, John

AU - Martin, Charles

AU - Jerabek, Paul

PY - 1997

Y1 - 1997

N2 - NON-INVASIVE imaging of human inter-regional neural connectivity by positron emission tomography (PET) during transcranial magnetic stimulation (TMS) was performed. The hand area of primary motor cortex (M1) in the left cerebral hemisphere was stimulated with TMS while local and remote effects were recorded with PET. At the stimulated site, TMS increased blood flow (12- 20%) in a highly focal manner, without an inhibitory surround. Remote covariances, an index of connectivity with M1, were also focal. Connectivity patterns established in non-human species were generally confirmed. Excitatory connectivity (positive covariance) was observed in ipsilateral primary and secondary somatosensory areas (S1 and S2), in ipsilateral ventral, lateral premotor cortex (M2) and in contralateral supplementary motor area (SMA). Inhibitory connectivity (negative covariance) was observed in contralateral M1.

AB - NON-INVASIVE imaging of human inter-regional neural connectivity by positron emission tomography (PET) during transcranial magnetic stimulation (TMS) was performed. The hand area of primary motor cortex (M1) in the left cerebral hemisphere was stimulated with TMS while local and remote effects were recorded with PET. At the stimulated site, TMS increased blood flow (12- 20%) in a highly focal manner, without an inhibitory surround. Remote covariances, an index of connectivity with M1, were also focal. Connectivity patterns established in non-human species were generally confirmed. Excitatory connectivity (positive covariance) was observed in ipsilateral primary and secondary somatosensory areas (S1 and S2), in ipsilateral ventral, lateral premotor cortex (M2) and in contralateral supplementary motor area (SMA). Inhibitory connectivity (negative covariance) was observed in contralateral M1.

KW - Connectivity

KW - Human

KW - M2

KW - Positron emission tomography (PET)

KW - Primary motor cortex (M1)

KW - S1

KW - S2

KW - SMA

KW - Transcranial magnetic stimulation (TMS)

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U2 - 10.1097/00001756-199708180-00027

DO - 10.1097/00001756-199708180-00027

M3 - Article

C2 - 9295118

AN - SCOPUS:0030803677

SN - 0959-4965

VL - 8

SP - 2787

EP - 2791

JO - NeuroReport

JF - NeuroReport

IS - 12

ER -

Imaging human intra-cerebral connectivity by PET during TMS

Abstract

Keywords

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