Imaging-Guided Microarray: Isolating Molecular Profiles That Dissociate Alzheimer's Disease from Normal Aging

Ana Pereira, William Wu, Scott A. Small

Research output: Contribution to journalArticlepeer-review

Abstract

Although both Alzheimer's disease (AD) and normal aging contribute to age-related hippocampal dysfunction, they are likely governed by separate molecular mechanisms. In principle, gene expression profiling can offer molecular clues about underlying mechanisms, but in practice techniques like microarray present unique analytic challenges when applied to disorders of the brain. Imaging-guided microarray is an approach designed to address these analytic challenges. Here, we will first review findings applying variants of functional magnetic resonance imaging (fMRI) to AD and normal aging, establishing the spatiotemporal profiles that dissociate one from the other. Then, we will review preliminary findings applying imaging-guided microarray to AD and normal aging, in an attempt to isolate molecular profiles that dissociate the two main causes of age-related hippocampal dysfunction.
Original languageAmerican English
Pages (from-to)225-238
Number of pages13
Journal Annals of the New York Academy of Sciences
Volume1097
Issue number1
DOIs
StatePublished - 2 Apr 2007

Fingerprint

Dive into the research topics of 'Imaging-Guided Microarray: Isolating Molecular Profiles That Dissociate Alzheimer's Disease from Normal Aging'. Together they form a unique fingerprint.

Cite this