TY - JOUR
T1 - IL10 polymorphisms associated with Behçet's disease in Chinese Han
AU - Wu, Ziyan
AU - Zheng, Wenjie
AU - Xu, Juanjuan
AU - Sun, Fei
AU - Chen, Hua
AU - Li, Ping
AU - Chen, Si
AU - Shen, Ming
AU - Zhang, Wen
AU - You, Xin
AU - Wu, Qingjun
AU - Zhang, Fengchun
AU - Li, Yongzhe
N1 - Funding Information:
This work was supported by funding from National Program on Key Research Project of New Drug Innovation No. 2012ZX09303006-002 , the Research Special Fund for Public Welfare Industry of Health No. 201202004 (to F-C. Z.), and the National Natural Science Foundation of China Grants 81072486 , 81172857 (to Y.-Z. L.).
PY - 2014/3
Y1 - 2014/3
N2 - Objective: IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. Methods: 407 BD patients and 679 healthy controls were enrolled, and genotyped by Sequenom MassArray system (Sequenom iPLEX assay, San Diego, CA). Results: The frequency of risk allele of rs1800871 was notably higher in BD patients than in controls (71.9% vs. 66.2%, OR: 1.30, 95%CI: 1.08-1.58, pc=0.024). Similarly, rs1518111, which showed strong linkage disequilibrium (r2=1) with allele rs1800871, was also associated with BD (pc=0.026). Rs3021094 was in association with BD in a dominant model (pc=0.035), and the haplotype (GACC) formed by rs1518111, rs3021094, rs3790622, and rs1800871 was associated with BD (pc=0.023). Results obtained from meta-analysis combined with our data showed that rs1800871 and rs1518111 were associated with BD. Conclusion: IL10 may be the susceptibility gene for BD in Chinese Han population.
AB - Objective: IL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet's disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han. Methods: 407 BD patients and 679 healthy controls were enrolled, and genotyped by Sequenom MassArray system (Sequenom iPLEX assay, San Diego, CA). Results: The frequency of risk allele of rs1800871 was notably higher in BD patients than in controls (71.9% vs. 66.2%, OR: 1.30, 95%CI: 1.08-1.58, pc=0.024). Similarly, rs1518111, which showed strong linkage disequilibrium (r2=1) with allele rs1800871, was also associated with BD (pc=0.026). Rs3021094 was in association with BD in a dominant model (pc=0.035), and the haplotype (GACC) formed by rs1518111, rs3021094, rs3790622, and rs1800871 was associated with BD (pc=0.023). Results obtained from meta-analysis combined with our data showed that rs1800871 and rs1518111 were associated with BD. Conclusion: IL10 may be the susceptibility gene for BD in Chinese Han population.
UR - http://www.scopus.com/inward/record.url?scp=84893733575&partnerID=8YFLogxK
U2 - 10.1016/j.humimm.2013.11.009
DO - 10.1016/j.humimm.2013.11.009
M3 - Article
C2 - 24269690
AN - SCOPUS:84893733575
SN - 0198-8859
VL - 75
SP - 271
EP - 276
JO - Human Immunology
JF - Human Immunology
IS - 3
ER -