IL-22 mediates the oral mucosal wound healing via STAT3 in keratinocytes

Ran Yu, Yumei Ding, Lijuan Zhu, Yinying Qu, Chenguang Zhang, Lin Liu, Lili Chen

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Objective Wounds are common in the oral cavity. During wound healing, several cytokines are released, which are probably helpful in providing wound debridement, removal of damaged tissues and microbes. Most of the target cells of IL-22 are epithelial cells, which play an important role in mucosa immunity. Design The function of IL-22 in oral diseases is not well understood. We investigated the expression level of IL-22, collagen I and p-stat3 (Tyr705) via a mice tongue wound model in vivo and detected the effect of IL-22 on the expression of MMP-1, type I collagen and p-stat3 in keratinocytes. Results IL-22 and p-stat3 were associated with wound healing, and STAT3 was activated when the keratinocytes or the tongue tissue were stimulated by IL-22. In addition, IL-22 could mediate gene expression involved in wounds involving keratinocytes, such as type I collagen and MMP-1, which may contribute to scarless healing. Conclusion Our study suggests that IL-22 mediates wound healing via STAT3 in keratinocytes. This study reveals a new role for IL-22 in mediating wound healing.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalArchives of Oral Biology
StatePublished - 1 Dec 2016
Externally publishedYes


  • IL-22
  • STAT3
  • Wound healing


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