IL-15: A central regulator of celiac disease immunopathology

Valérie Abadie, Bana Jabri

Research output: Contribution to journalReview articlepeer-review

176 Scopus citations

Abstract

Interleukin-15 (IL-15) exerts many biological functions essential for the maintenance and function of multiple cell types. Although its expression is tightly regulated, IL-15 upregulation has been reported in many organ-specific autoimmune disorders. In celiac disease, an intestinal inflammatory disorder driven by gluten exposure, the upregulation of IL-15 expression in the intestinal mucosa has become a hallmark of the disease. Interestingly, because it is overexpressed both in the gut epithelium and in the lamina propria, IL-15 acts on distinct cell types and impacts distinct immune components and pathways to disrupt intestinal immune homeostasis. In this article, we review our current knowledge of the multifaceted roles of IL-15 with regard to the main immunological processes involved in the pathogenesis of celiac disease.

Original languageEnglish
Pages (from-to)221-234
Number of pages14
JournalImmunological Reviews
Volume260
Issue number1
DOIs
StatePublished - Jul 2014
Externally publishedYes

Keywords

  • Autoimmunity
  • Celiac disease
  • Cytotoxic T cells
  • IL-15
  • Loss of oral tolerance
  • Tissue

Fingerprint

Dive into the research topics of 'IL-15: A central regulator of celiac disease immunopathology'. Together they form a unique fingerprint.

Cite this