TY - JOUR
T1 - IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines
AU - Santini, Maria Paola
AU - Lexow, Jonas
AU - Borsellino, Giovanna
AU - Slonimski, Esfir
AU - Zarrinpashneh, Elham
AU - Poggioli, Tommaso
AU - Rosenthal, Nadia
N1 - Funding Information:
We thank all the members of Rosenthal’s laboratory at the Heart Science Centre for critical analysis of the manuscript. This work has been supported by the Principal Investigator Founding to Professor Rosenthal and by the European Union (QLRT-2001–00930), the Foundation Leducq, and Ricerca Finalizzata (Italian Ministry of Health). Nadia Rosenthal is an NHMRC Australia Fellow.
PY - 2011/7/1
Y1 - 2011/7/1
N2 - The aim of this study was to investigate whether supplemental IGF-1Ea transgene expression induces activation of local cardiac and bone marrow stem cell population to mediate mammalian heart repair. In physiologic conditions, cardiac overexpression of the IGF-1Ea propeptide is associated with an enrichment of c-Kit/Sca-1 positive side population cells in the bone marrow and the occurrence of an endothelial-primed CD34 positive side population in the heart. This cellular profile is shown here to correlate with the expression of cytokines involved in stem cell mobilization and vessel formation. This molecular and cellular interplay favored IGF-1Ea-mediated vessel formation in injured hearts. The physiologic and pathologic connection between cytokines and stem cells in response to IGF-1Ea may represent an important model to understand how to elicit endogenous reparative signaling.
AB - The aim of this study was to investigate whether supplemental IGF-1Ea transgene expression induces activation of local cardiac and bone marrow stem cell population to mediate mammalian heart repair. In physiologic conditions, cardiac overexpression of the IGF-1Ea propeptide is associated with an enrichment of c-Kit/Sca-1 positive side population cells in the bone marrow and the occurrence of an endothelial-primed CD34 positive side population in the heart. This cellular profile is shown here to correlate with the expression of cytokines involved in stem cell mobilization and vessel formation. This molecular and cellular interplay favored IGF-1Ea-mediated vessel formation in injured hearts. The physiologic and pathologic connection between cytokines and stem cells in response to IGF-1Ea may represent an important model to understand how to elicit endogenous reparative signaling.
KW - Angiogenesis
KW - Cardiac regeneration
KW - IGF-1Ea
KW - Side population
UR - https://www.scopus.com/pages/publications/79959733942
U2 - 10.1016/j.bbrc.2011.05.081
DO - 10.1016/j.bbrc.2011.05.081
M3 - Article
C2 - 21621517
AN - SCOPUS:79959733942
SN - 0006-291X
VL - 410
SP - 201
EP - 207
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -