IgA Summons IgG to Take a Hit at HIV-1

Giuliana Magri; Andrea Cerutti

doi:10.1016/j.chom.2020.05.017

IgA Summons IgG to Take a Hit at HIV-1

Giuliana Magri, Andrea Cerutti

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

Original language	English
Pages (from-to)	854-856
Number of pages	3
Journal	Cell Host and Microbe
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2020.05.017
State	Published - 10 Jun 2020

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title = "IgA Summons IgG to Take a Hit at HIV-1",

abstract = "In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.",

author = "Giuliana Magri and Andrea Cerutti",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

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doi = "10.1016/j.chom.2020.05.017",

language = "English",

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journal = "Cell Host and Microbe",

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T1 - IgA Summons IgG to Take a Hit at HIV-1

AU - Magri, Giuliana

AU - Cerutti, Andrea

PY - 2020/6/10

Y1 - 2020/6/10

N2 - In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

AB - In this issue of Cell Host & Microbe, Jia et al. used a vesicular stomatitis virus-based probe to isolate B cells expressing broadly neutralizing HIV-1 antibodies. Besides identifying neutralizing epitopes, this study highlights potential protection afforded by IgA arising from either direct IgM-to-IgA or sequential IgM-to-IgG-to-IgA class switching.

UR - http://www.scopus.com/inward/record.url?scp=85085898550&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2020.05.017

DO - 10.1016/j.chom.2020.05.017

M3 - Comment/debate

C2 - 32526180

AN - SCOPUS:85085898550

SN - 1931-3128

VL - 27

SP - 854

EP - 856

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

IgA Summons IgG to Take a Hit at HIV-1

Abstract

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