IgA Nephropathy in Northern Jordan: Evaluation Using the MEST-C Score of Oxford Classification System

IgA nephropathy (IgAN) is the most common primary glomerular disease worldwide. However, predicting prognosis from the histopathological evaluation of a tissue biopsy has not been well-established until recently. The aim of this research is to evaluate IgAN patients in Northern Jordan by the MEST-C score of Oxford Classification System. Clinical data and histopathology reports of twenty-seven patients diagnosed with IgAN were retrospectively reviewed. These data were retrieved from the electronic health information system of King Abdullah University hospital. The results showed a male predominance (70 %) and a mean age of (24 ± 16) years at diagnosis. MEST-C Oxford classification was as follows: five (18.5 %) patients had mesangial hypercellularity (M1), six (22.2 %) patients had endo-capillary hypercellularity (E1), eight (29.6 %) patients had segmental glomerulosclerosis (S1), four (14.8 %) patients had interstitial fibrosis/tubular atrophy (IFTA) score of (T1) and (0 %) had a score of (T2). As for crescents, three (11.1 %) had (C1) and one (3.7 %) had (C2). A significant negative correlation was found between the final estimated glomerular filtration rate (eGFR) at follow-up and the total MEST-C score (Spearman’s Rho = 0.460, p<0.05). Histopathological parameters represented by the MEST-C Score of Oxford Classification can predict outcome in the study’s cohort, and is similar to previous published studies.