Idiopathic early ovarian aging: is there a relation with premenopausal accelerated biological aging in young women with diminished response to ART?

Mette W. Christensen, David L. Keefe, Fang Wang, Christine S. Hansen, Isaac J. Chamani, Carolyn Sommer, Mette Nyegaard, Palle D. Rohde, Anders L. Nielsen, Jonas Bybjerg-Grauholm, Ulrik S. Kesmodel, Ulla B. Knudsen, Kirstine Kirkegaard, Hans Jakob Ingerslev

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Purpose: To evaluate whether young women with idiopathic early ovarian aging, as defined by producing fewer oocytes than expected for a given age over multiple in vitro fertilization (IVF) cycles, have changes in telomere length and epigenetic age indicating accelerated biological aging (i.e., increased risk of morbidity and mortality). Methods: A prospective cohort study was conducted at two Danish public fertility clinics. A total of 55 young women (≤ 37 years) with at least two IVF cycles with ≤ 5 harvested oocytes despite sufficient stimulation with follicle-stimulating hormone (FSH) were included in the early ovarian aging group. As controls, 52 young women (≤ 37 years) with normal ovarian function, defined by at least eight harvested oocytes, were included. Relative telomere length (rTL) and epigenetic age acceleration (AgeAccel) were measured in white blood cells as markers of premenopausal accelerated biological aging. Results: rTL was comparable with a mean of 0.46 (± SD 0.12) in the early ovarian aging group and 0.47 (0.14) in the normal ovarian aging group. The AgeAccel of the early ovarian aging group was, insignificantly, 0.5 years older, but this difference disappeared when adjusting for chronological age. Sub-analysis using Anti-Müllerian hormone (AMH) as selection criterion for the two groups did not change the results. Conclusion: We did not find any indications of accelerated aging in whole blood from young women with idiopathic early ovarian aging. Further investigations in a similar cohort of premenopausal women or other tissues are needed to fully elucidate the potential relationship between premenopausal accelerated biological aging and early ovarian aging.

Original languageEnglish
Pages (from-to)3027-3038
Number of pages12
JournalJournal of Assisted Reproduction and Genetics
Volume38
Issue number11
DOIs
StatePublished - Nov 2021
Externally publishedYes

Keywords

  • Accelerated aging
  • Early ovarian aging
  • Epigenetics
  • Telomere

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