TY - JOUR
T1 - Identifying High-Risk Stage II Colon Cancer Patients
T2 - A Three-MicroRNA-Based Score as a Prognostic Biomarker
AU - Caritg, Oriol
AU - Navarro, Alfons
AU - Moreno, Isabel
AU - Martínez-Rodenas, Francisco
AU - Cordeiro, Anna
AU - Muñoz, Carmen
AU - Ruiz-Martinez, Marc
AU - Santasusagna, Sandra
AU - Castellano, Joan Josep
AU - Monzó, Mariano
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Adjuvant treatment for patients with stage II colon cancer remains controversial. We tested a panel of microRNAs to identify high-risk stage II colon cancer patients who would potentially benefit from postoperative chemotherapy. We constructed a simple 3-microRNA-based score that can predict the prognosis in this subset of patients. Background The potential benefit of adjuvant chemotherapy in surgically resected patients with stage II colorectal cancer is controversial. The current guidelines, which are based solely on clinical factors, have limited usefulness, and a clear need exists for biomarkers to supplement the clinical information. MicroRNAs (miRNAs) have previously been shown to be useful cancer biomarkers. In the present study, we assessed the usefulness of a miRNA score to help identify the subset of high-risk patients likely to benefit from adjuvant chemotherapy. Patients and Methods Six miRNAs previously identified as prognostic markers in Asian patients (miR-21-5p, miR-20a-5p, miR-103a-3p, miR-106b-5p, miR-143-5p, and miR-215) were studied in tumor samples from 71 white patients with stage II colon cancer. Results Three miRNAs (miR-103a-3p, miR-143-5p, and miR-215) emerged as independent prognostic markers on multivariate analysis and were used to construct a miRNA-based score that classified patients into high- and low-risk groups. The patients in the high-risk group had significantly shorter disease-free survival compared with their low-risk counterparts (P = .003). The time-dependent receiver operating characteristic curve analysis showed that our 3-miRNA score improved the prediction of outcome when added to the clinical features (P = .023). Conclusion Our 3-miRNA score added valuable prognostic information to the clinical features in stage II colon cancer. Further research in this field could provide useful tools to determine whether adjuvant chemotherapy would benefit patients with stage II colon cancer after surgery.
AB - Adjuvant treatment for patients with stage II colon cancer remains controversial. We tested a panel of microRNAs to identify high-risk stage II colon cancer patients who would potentially benefit from postoperative chemotherapy. We constructed a simple 3-microRNA-based score that can predict the prognosis in this subset of patients. Background The potential benefit of adjuvant chemotherapy in surgically resected patients with stage II colorectal cancer is controversial. The current guidelines, which are based solely on clinical factors, have limited usefulness, and a clear need exists for biomarkers to supplement the clinical information. MicroRNAs (miRNAs) have previously been shown to be useful cancer biomarkers. In the present study, we assessed the usefulness of a miRNA score to help identify the subset of high-risk patients likely to benefit from adjuvant chemotherapy. Patients and Methods Six miRNAs previously identified as prognostic markers in Asian patients (miR-21-5p, miR-20a-5p, miR-103a-3p, miR-106b-5p, miR-143-5p, and miR-215) were studied in tumor samples from 71 white patients with stage II colon cancer. Results Three miRNAs (miR-103a-3p, miR-143-5p, and miR-215) emerged as independent prognostic markers on multivariate analysis and were used to construct a miRNA-based score that classified patients into high- and low-risk groups. The patients in the high-risk group had significantly shorter disease-free survival compared with their low-risk counterparts (P = .003). The time-dependent receiver operating characteristic curve analysis showed that our 3-miRNA score improved the prediction of outcome when added to the clinical features (P = .023). Conclusion Our 3-miRNA score added valuable prognostic information to the clinical features in stage II colon cancer. Further research in this field could provide useful tools to determine whether adjuvant chemotherapy would benefit patients with stage II colon cancer after surgery.
KW - Adjuvant chemotherapy
KW - Disease-free survival
KW - miR-103a
KW - miR-143-5p
KW - miR-215
UR - https://www.scopus.com/pages/publications/84969974180
U2 - 10.1016/j.clcc.2016.04.008
DO - 10.1016/j.clcc.2016.04.008
M3 - Article
C2 - 27247088
AN - SCOPUS:84969974180
SN - 1533-0028
VL - 15
SP - e175-e182
JO - Clinical Colorectal Cancer
JF - Clinical Colorectal Cancer
IS - 4
ER -