Identification of high levels of protein phosphatase-1 in rat liver nuclei

Jeff Kuret; Heather Bell; Philip Cohen

doi:10.1016/0014-5793(86)80741-4

Identification of high levels of protein phosphatase-1 in rat liver nuclei

Jeff Kuret
, Heather Bell
, Philip Cohen

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

Original language	English
Pages (from-to)	197-202
Number of pages	6
Journal	FEBS Letters
Volume	203
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(86)80741-4
State	Published - 28 Jul 1986
Externally published	Yes

Keywords

(Rat liver)
Metabolic regulation
Nucleus
Protein phosphatase
Protein phosphorylation

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10.1016/0014-5793(86)80741-4

Cite this

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title = "Identification of high levels of protein phosphatase-1 in rat liver nuclei",

abstract = "Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.",

keywords = "(Rat liver), Metabolic regulation, Nucleus, Protein phosphatase, Protein phosphorylation",

author = "Jeff Kuret and Heather Bell and Philip Cohen",

year = "1986",

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doi = "10.1016/0014-5793(86)80741-4",

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T1 - Identification of high levels of protein phosphatase-1 in rat liver nuclei

AU - Kuret, Jeff

AU - Bell, Heather

AU - Cohen, Philip

PY - 1986/7/28

Y1 - 1986/7/28

N2 - Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

AB - Rat liver nuclei contain a protein phosphatase that is indistinguishable from the catalytic subunit of protein phosphatase-1 in its molecular mass, sensitivity to inhibitor-1 and inhibitor-2 and specificity for the β-subunit of phosphorylase kinase. This activity is not bound to the outer nuclear membrane, but located within the nucleus. The average level of protein phosphatase-1 activity in nuclei is at least 5-fold higher than its average extranuclear concentration.

KW - (Rat liver)

KW - Metabolic regulation

KW - Nucleus

KW - Protein phosphatase

KW - Protein phosphorylation

UR - https://www.scopus.com/pages/publications/0022450582

U2 - 10.1016/0014-5793(86)80741-4

DO - 10.1016/0014-5793(86)80741-4

M3 - Article

C2 - 3015674

AN - SCOPUS:0022450582

SN - 0014-5793

VL - 203

SP - 197

EP - 202

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Identification of high levels of protein phosphatase-1 in rat liver nuclei

Abstract

Keywords

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