Identification of gene microarray expression profiles in patients with chronic graft-versus-host disease following allogeneic hematopoietic cell transplantation

Holbrook E. Kohrt, Lu Tian, Li Li, Ash A. Alizadeh, Sue Hsieh, Robert J. Tibshirani, Samuel Strober, Minnie Sarwal, Robert Lowsky

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Chronic graft-versus-host disease (GVHD) results in significant morbidity and mortality, limiting the benefit of allogeneic hematopoietic cell transplantation (HCT). Peripheral blood gene expression profiling of the donor immune repertoire following HCT may provide associated genes and pathways thereby improving the pathophysiologic understanding of chronic GVHD. We profiled 70 patients and identified candidate genes that provided mechanistic insight in the biologic pathways that underlie chronic GVHD. Our data revealed that the dominant gene signature in patients with chronic GVHD represented compensatory responses that control inflammation and included the interleukin-1 decoy receptor, IL-1 receptor type II, and genes that were profibrotic and associated with the IL-4, IL-6 and IL-10 signaling pathways. In addition, we identified three genes that were important regulators of extracellular matrix. Validation of this discovery phase study will determine if the identified genes have diagnostic, prognostic or therapeutic implications.

Original languageEnglish
Pages (from-to)124-135
Number of pages12
JournalClinical Immunology
Volume148
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • Gene expression
  • Genomic markers
  • Graft-versus-host-disease

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