Identification of a UV-induced trans-acting protein that stimulates polyomavirus DNA replication.

Z. A. Ronai; I. B. Weinstein

doi:10.1128/jvi.62.3.1057-1060.1988

Identification of a UV-induced trans-acting protein that stimulates polyomavirus DNA replication.

Z. A. Ronai, I. B. Weinstein

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Abstract

Previous studies provided indirect evidence that the ability of a variety of DNA-damaging agents to induce asynchronous polyomavirus DNA replication in the H3 rat fibroblast cell line is mediated by a trans-acting factor. Using an erythrocyte insertion technique to introduce protein fractions from UV-irradiated cells into unirradiated H3 cells, we have now obtained evidence that this factor is a 60-kilodalton protein. These findings provide evidence that DNA damage in mammalian cells induces a factor that can alter the replication of a viral DNA.

Original language	English
Pages (from-to)	1057-1060
Number of pages	4
Journal	Journal of Virology
Volume	62
Issue number	3
DOIs	https://doi.org/10.1128/jvi.62.3.1057-1060.1988
State	Published - Mar 1988
Externally published	Yes

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10.1128/jvi.62.3.1057-1060.1988

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title = "Identification of a UV-induced trans-acting protein that stimulates polyomavirus DNA replication.",

abstract = "Previous studies provided indirect evidence that the ability of a variety of DNA-damaging agents to induce asynchronous polyomavirus DNA replication in the H3 rat fibroblast cell line is mediated by a trans-acting factor. Using an erythrocyte insertion technique to introduce protein fractions from UV-irradiated cells into unirradiated H3 cells, we have now obtained evidence that this factor is a 60-kilodalton protein. These findings provide evidence that DNA damage in mammalian cells induces a factor that can alter the replication of a viral DNA.",

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AB - Previous studies provided indirect evidence that the ability of a variety of DNA-damaging agents to induce asynchronous polyomavirus DNA replication in the H3 rat fibroblast cell line is mediated by a trans-acting factor. Using an erythrocyte insertion technique to introduce protein fractions from UV-irradiated cells into unirradiated H3 cells, we have now obtained evidence that this factor is a 60-kilodalton protein. These findings provide evidence that DNA damage in mammalian cells induces a factor that can alter the replication of a viral DNA.

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Identification of a UV-induced trans-acting protein that stimulates polyomavirus DNA replication.

Abstract

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