Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy

W. J. Burtis, T. Wu, C. Bunch, J. J. Wysolmerski, K. L. Insogna, E. C. Weir, A. E. Broadus, A. F. Stewart

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Abstract

Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome which is characterized by hypercalcemia resulting from secretion by tumors of a circulating bone-resorbing factor. Evidence suggests that in many instances this factor is an adenylate cyclase-stimulating protein which share features with, but is distinct from, parathyroid hormone (PTH). The current report describes the purification to homogeneity from a humoral hypercalcemia of malignancy-associated tumor a novel, basic, highly potent PTH-like adenylate cyclase-stimulating protein. This factor differs from previously described PTH-like factors with respect to size, amino acid composition, and specific activity.

Original languageEnglish
Pages (from-to)7151-7156
Number of pages6
JournalJournal of Biological Chemistry
Volume262
Issue number15
StatePublished - 1987

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